| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-09-10 17:00 | Espanyol Barcelona | UD Almeria | 1:0 |
| 18-09-10 17:00 | RCD Mallorca | CA Osasuna | 2:0 |
| 18-09-10 19:00 | Sporting Gijón | Athletic Bilbao | 2:2 |
| 18-09-10 21:00 | Real Sociedad | Real Madrid | 1:2 |
| 19-09-10 16:00 | Hercules Alicante | FC Valencia | 1:2 |
| 19-09-10 16:00 | Racing Santander | Real Zaragoza | 2:0 |
| 19-09-10 16:00 | UD Levante | FC Villarreal | 1:2 |
| 19-09-10 18:00 | Atlético Madrid | FC Barcelona | 1:2 |
| 19-09-10 20:00 | FC Málaga | FC Sevilla | 1:2 |
| 20-09-10 20:00 | Deportivo La Coruña | FC Getafe | 2:2 |