| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 20-05-22 20:00 | Real Madrid | Real Betis Sevilla | 0:0 |
| 20-05-22 20:00 | Rayo Vallecano | UD Levante | 2:4 |
| 21-05-22 16:30 | FC Valencia | Celta Vigo | 2:0 |
| 22-05-22 16:30 | FC Elche | FC Getafe | 3:1 |
| 22-05-22 19:00 | Deportivo Alavés | FC Cádiz | 0:1 |
| 22-05-22 19:00 | FC Granada | Espanyol Barcelona | 0:0 |
| 22-05-22 19:00 | CA Osasuna | RCD Mallorca | 0:2 |
| 22-05-22 21:00 | FC Barcelona | FC Villarreal | 0:2 |
| 22-05-22 21:00 | Real Sociedad | Atlético Madrid | 1:2 |
| 22-05-22 21:00 | FC Sevilla | Athletic Bilbao | 1:0 |