| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-09-10 17:00 | FC Barcelona | Hercules Alicante | 0:2 |
| 11-09-10 17:00 | FC Valencia | Racing Santander | 1:0 |
| 11-09-10 19:00 | Real Madrid | CA Osasuna | 1:0 |
| 11-09-10 21:00 | Athletic Bilbao | Atlético Madrid | 1:2 |
| 12-09-10 16:00 | FC Getafe | UD Levante | 4:1 |
| 12-09-10 16:00 | Sporting Gijón | RCD Mallorca | 2:0 |
| 12-09-10 16:00 | Real Zaragoza | FC Málaga | 3:5 |
| 12-09-10 18:00 | FC Villarreal | Espanyol Barcelona | 4:0 |
| 12-09-10 20:00 | FC Sevilla | Deportivo La Coruña | 0:0 |
| 13-09-10 20:00 | UD Almeria | Real Sociedad | 2:2 |