| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-12-10 17:00 | FC Getafe | FC Villarreal | 1:0 |
| 11-12-10 19:00 | FC Sevilla | UD Almeria | 1:3 |
| 11-12-10 21:00 | Atlético Madrid | Deportivo La Coruña | 2:0 |
| 12-12-10 16:00 | Athletic Bilbao | Espanyol Barcelona | 2:1 |
| 12-12-10 16:00 | Sporting Gijón | UD Levante | 1:1 |
| 12-12-10 16:00 | Hercules Alicante | FC Málaga | 4:1 |
| 12-12-10 16:00 | RCD Mallorca | Racing Santander | 0:1 |
| 12-12-10 18:00 | Real Zaragoza | Real Madrid | 1:3 |
| 12-12-10 20:00 | FC Barcelona | Real Sociedad | 5:0 |
| 13-12-10 20:00 | FC Valencia | CA Osasuna | 3:3 |