| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 16-10-21 17:30 | UD Levante | FC Getafe | 0:0 |
| 16-10-21 20:00 | Real Sociedad | RCD Mallorca | 1:0 |
| 17-10-21 13:00 | Rayo Vallecano | FC Elche | 2:1 |
| 17-10-21 15:15 | Celta Vigo | FC Sevilla | 0:1 |
| 17-10-21 17:30 | FC Villarreal | CA Osasuna | 1:2 |
| 17-10-21 20:00 | FC Barcelona | FC Valencia | 3:1 |
| 18-10-21 18:00 | Deportivo Alavés | Real Betis Sevilla | 0:1 |
| 18-10-21 20:00 | Espanyol Barcelona | FC Cádiz | 2:0 |
| 01-12-21 20:00 | Real Madrid | Athletic Bilbao | 1:0 |
| 22-12-21 18:00 | FC Granada | Atlético Madrid | 2:1 |