| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 01-10-21 20:00 | Athletic Bilbao | Deportivo Alavés | 1:0 |
| 02-10-21 13:00 | CA Osasuna | Rayo Vallecano | 1:0 |
| 02-10-21 15:15 | RCD Mallorca | UD Levante | 1:0 |
| 02-10-21 17:30 | FC Cádiz | FC Valencia | 0:0 |
| 02-10-21 20:00 | Atlético Madrid | FC Barcelona | 2:0 |
| 03-10-21 13:00 | FC Elche | Celta Vigo | 1:0 |
| 03-10-21 15:15 | Espanyol Barcelona | Real Madrid | 2:1 |
| 03-10-21 17:30 | FC Getafe | Real Sociedad | 1:1 |
| 03-10-21 17:30 | FC Villarreal | Real Betis Sevilla | 2:0 |
| 03-10-21 20:00 | FC Granada | FC Sevilla | 1:0 |