| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-09-21 18:30 | FC Getafe | Atlético Madrid | 1:2 |
| 21-09-21 21:00 | Athletic Bilbao | Rayo Vallecano | 1:2 |
| 21-09-21 21:00 | UD Levante | Celta Vigo | 0:2 |
| 22-09-21 18:30 | Espanyol Barcelona | Deportivo Alavés | 1:0 |
| 22-09-21 18:30 | FC Sevilla | FC Valencia | 3:1 |
| 22-09-21 21:00 | Real Madrid | RCD Mallorca | 6:1 |
| 22-09-21 21:00 | FC Villarreal | FC Elche | 4:1 |
| 23-09-21 18:30 | FC Granada | Real Sociedad | 2:3 |
| 23-09-21 18:30 | CA Osasuna | Real Betis Sevilla | 1:3 |
| 23-09-21 21:00 | FC Cádiz | FC Barcelona | 0:0 |