| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-09-21 17:30 | UD Levante | Rayo Vallecano | 1:1 |
| 11-09-21 20:00 | Athletic Bilbao | RCD Mallorca | 2:0 |
| 12-09-21 13:00 | Espanyol Barcelona | Atlético Madrid | 1:2 |
| 12-09-21 15:15 | CA Osasuna | FC Valencia | 1:4 |
| 12-09-21 17:30 | FC Cádiz | Real Sociedad | 0:2 |
| 12-09-21 20:00 | Real Madrid | Celta Vigo | 5:2 |
| 13-09-21 19:00 | FC Getafe | FC Elche | 0:1 |
| 13-09-21 21:00 | FC Granada | Real Betis Sevilla | 1:2 |
| 21-12-21 18:00 | FC Villarreal | Deportivo Alavés | 5:2 |
| 21-12-21 20:30 | FC Sevilla | FC Barcelona | 1:1 |