| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 14-05-22 17:30 | Espanyol Barcelona | FC Valencia | 1:1 |
| 15-05-22 18:30 | Athletic Bilbao | CA Osasuna | 2:0 |
| 15-05-22 18:30 | Atlético Madrid | FC Sevilla | 1:1 |
| 15-05-22 18:30 | Real Betis Sevilla | FC Granada | 2:0 |
| 15-05-22 18:30 | Celta Vigo | FC Elche | 1:0 |
| 15-05-22 18:30 | RCD Mallorca | Rayo Vallecano | 2:1 |
| 15-05-22 18:30 | FC Getafe | FC Barcelona | 0:0 |
| 15-05-22 18:30 | FC Cádiz | Real Madrid | 1:1 |
| 15-05-22 18:30 | UD Levante | Deportivo Alavés | 3:1 |
| 15-05-22 18:30 | FC Villarreal | Real Sociedad | 1:2 |