| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 10-05-22 18:00 | FC Valencia | Real Betis Sevilla | 0:3 |
| 10-05-22 19:00 | FC Granada | Athletic Bilbao | 1:0 |
| 10-05-22 20:30 | FC Barcelona | Celta Vigo | 3:1 |
| 11-05-22 18:00 | Deportivo Alavés | Espanyol Barcelona | 2:1 |
| 11-05-22 18:00 | CA Osasuna | FC Getafe | 1:1 |
| 11-05-22 19:30 | FC Sevilla | RCD Mallorca | 0:0 |
| 11-05-22 20:30 | FC Elche | Atlético Madrid | 0:2 |
| 12-05-22 18:00 | Real Sociedad | FC Cádiz | 3:0 |
| 12-05-22 19:00 | Rayo Vallecano | FC Villarreal | 1:5 |
| 12-05-22 20:30 | Real Madrid | UD Levante | 6:0 |