| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 06-05-22 20:00 | UD Levante | Real Sociedad | 2:1 |
| 07-05-22 13:00 | RCD Mallorca | FC Granada | 2:6 |
| 07-05-22 15:15 | Athletic Bilbao | FC Valencia | 0:0 |
| 07-05-22 17:30 | FC Cádiz | FC Elche | 3:0 |
| 07-05-22 17:30 | Celta Vigo | Deportivo Alavés | 4:0 |
| 07-05-22 20:00 | Real Betis Sevilla | FC Barcelona | 1:2 |
| 08-05-22 13:00 | FC Getafe | Rayo Vallecano | 0:0 |
| 08-05-22 15:15 | FC Villarreal | FC Sevilla | 1:1 |
| 08-05-22 17:30 | Espanyol Barcelona | CA Osasuna | 1:1 |
| 08-05-22 20:00 | Atlético Madrid | Real Madrid | 1:0 |