| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 19-04-22 18:00 | RCD Mallorca | Deportivo Alavés | 2:1 |
| 19-04-22 20:00 | Real Betis Sevilla | FC Elche | 0:1 |
| 19-04-22 20:30 | FC Villarreal | FC Valencia | 2:0 |
| 20-04-22 18:00 | Atlético Madrid | FC Granada | 0:0 |
| 20-04-22 19:00 | Celta Vigo | FC Getafe | 0:2 |
| 20-04-22 20:30 | CA Osasuna | Real Madrid | 1:3 |
| 21-04-22 18:00 | Espanyol Barcelona | Rayo Vallecano | 0:1 |
| 21-04-22 18:00 | UD Levante | FC Sevilla | 2:3 |
| 21-04-22 19:00 | FC Cádiz | Athletic Bilbao | 2:3 |
| 21-04-22 20:30 | Real Sociedad | FC Barcelona | 0:1 |