| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 15-04-22 20:00 | Real Sociedad | Real Betis Sevilla | 0:0 |
| 16-04-22 13:00 | FC Elche | RCD Mallorca | 3:0 |
| 16-04-22 15:15 | Deportivo Alavés | Rayo Vallecano | 1:0 |
| 16-04-22 17:30 | FC Valencia | CA Osasuna | 1:2 |
| 16-04-22 20:00 | FC Getafe | FC Villarreal | 1:2 |
| 17-04-22 13:00 | FC Granada | UD Levante | 1:4 |
| 17-04-22 15:15 | Atlético Madrid | Espanyol Barcelona | 2:1 |
| 17-04-22 17:30 | Athletic Bilbao | Celta Vigo | 0:2 |
| 17-04-22 20:00 | FC Sevilla | Real Madrid | 2:3 |
| 18-04-22 20:00 | FC Barcelona | FC Cádiz | 0:1 |