| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 08-04-22 20:00 | FC Sevilla | FC Granada | 4:2 |
| 09-04-22 13:00 | FC Cádiz | Real Betis Sevilla | 1:2 |
| 09-04-22 15:15 | RCD Mallorca | Atlético Madrid | 1:0 |
| 09-04-22 17:30 | FC Villarreal | Athletic Bilbao | 1:1 |
| 09-04-22 20:00 | Real Madrid | FC Getafe | 2:0 |
| 10-04-22 13:00 | CA Osasuna | Deportivo Alavés | 1:0 |
| 10-04-22 15:15 | Espanyol Barcelona | Celta Vigo | 1:0 |
| 10-04-22 17:30 | FC Elche | Real Sociedad | 1:2 |
| 10-04-22 20:00 | UD Levante | FC Barcelona | 2:3 |
| 11-04-22 20:00 | Rayo Vallecano | FC Valencia | 1:1 |