| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-04-22 13:00 | FC Getafe | RCD Mallorca | 1:0 |
| 02-04-22 15:15 | UD Levante | FC Villarreal | 2:0 |
| 02-04-22 17:30 | Celta Vigo | Real Madrid | 1:2 |
| 02-04-22 20:00 | Atlético Madrid | Deportivo Alavés | 4:1 |
| 03-04-22 13:00 | Athletic Bilbao | FC Elche | 2:1 |
| 03-04-22 15:15 | Real Betis Sevilla | CA Osasuna | 4:1 |
| 03-04-22 17:30 | FC Granada | Rayo Vallecano | 2:2 |
| 03-04-22 17:30 | FC Valencia | FC Cádiz | 0:0 |
| 03-04-22 20:00 | FC Barcelona | FC Sevilla | 1:0 |
| 04-04-22 20:00 | Real Sociedad | Espanyol Barcelona | 1:0 |