| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-03-22 20:00 | Athletic Bilbao | FC Getafe | 1:1 |
| 19-03-22 13:00 | Deportivo Alavés | FC Granada | 2:3 |
| 19-03-22 15:15 | FC Elche | FC Valencia | 0:1 |
| 19-03-22 17:30 | CA Osasuna | UD Levante | 3:1 |
| 19-03-22 20:00 | Rayo Vallecano | Atlético Madrid | 0:1 |
| 20-03-22 13:00 | Espanyol Barcelona | RCD Mallorca | 1:0 |
| 20-03-22 15:15 | Celta Vigo | Real Betis Sevilla | 0:0 |
| 20-03-22 15:15 | FC Cádiz | FC Villarreal | 1:0 |
| 20-03-22 17:30 | FC Sevilla | Real Sociedad | 0:0 |
| 20-03-22 20:00 | Real Madrid | FC Barcelona | 0:4 |