| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-03-22 20:00 | Atlético Madrid | FC Cádiz | 2:1 |
| 12-03-22 13:00 | UD Levante | Espanyol Barcelona | 1:1 |
| 12-03-22 15:15 | FC Granada | FC Elche | 0:1 |
| 12-03-22 17:30 | FC Villarreal | Celta Vigo | 1:0 |
| 12-03-22 20:00 | FC Getafe | FC Valencia | 0:0 |
| 13-03-22 13:00 | Rayo Vallecano | FC Sevilla | 1:1 |
| 13-03-22 15:15 | Real Betis Sevilla | Athletic Bilbao | 1:0 |
| 13-03-22 17:30 | Real Sociedad | Deportivo Alavés | 1:0 |
| 13-03-22 20:00 | FC Barcelona | CA Osasuna | 4:0 |
| 14-03-22 20:00 | RCD Mallorca | Real Madrid | 0:3 |