| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 04-03-22 20:00 | Deportivo Alavés | FC Sevilla | 0:0 |
| 05-03-22 13:00 | CA Osasuna | FC Villarreal | 1:0 |
| 05-03-22 15:15 | Espanyol Barcelona | FC Getafe | 2:0 |
| 05-03-22 17:30 | FC Valencia | FC Granada | 3:1 |
| 05-03-22 20:00 | Real Madrid | Real Sociedad | 4:1 |
| 06-03-22 13:00 | FC Cádiz | Rayo Vallecano | 2:0 |
| 06-03-22 15:15 | FC Elche | FC Barcelona | 1:2 |
| 06-03-22 17:30 | Celta Vigo | RCD Mallorca | 4:3 |
| 06-03-22 20:00 | Real Betis Sevilla | Atlético Madrid | 1:3 |
| 07-03-22 20:00 | Athletic Bilbao | UD Levante | 3:1 |