| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 25-02-22 20:00 | UD Levante | FC Elche | 3:0 |
| 26-02-22 13:00 | RCD Mallorca | FC Valencia | 0:1 |
| 26-02-22 15:15 | FC Getafe | Deportivo Alavés | 2:2 |
| 26-02-22 17:30 | Rayo Vallecano | Real Madrid | 0:1 |
| 26-02-22 20:00 | Atlético Madrid | Celta Vigo | 2:0 |
| 27-02-22 13:00 | FC Villarreal | Espanyol Barcelona | 5:1 |
| 27-02-22 15:15 | FC Sevilla | Real Betis Sevilla | 2:1 |
| 27-02-22 17:30 | Real Sociedad | CA Osasuna | 1:0 |
| 27-02-22 20:00 | FC Barcelona | Athletic Bilbao | 4:0 |
| 28-02-22 20:00 | FC Granada | FC Cádiz | 0:0 |