| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-02-22 20:00 | FC Elche | Rayo Vallecano | 2:1 |
| 19-02-22 13:00 | FC Granada | FC Villarreal | 1:4 |
| 19-02-22 15:15 | CA Osasuna | Atlético Madrid | 0:3 |
| 19-02-22 17:30 | FC Cádiz | FC Getafe | 1:1 |
| 19-02-22 20:00 | Real Madrid | Deportivo Alavés | 3:0 |
| 20-02-22 13:00 | Espanyol Barcelona | FC Sevilla | 1:1 |
| 20-02-22 15:15 | FC Valencia | FC Barcelona | 1:4 |
| 20-02-22 17:30 | Real Betis Sevilla | RCD Mallorca | 2:1 |
| 20-02-22 20:00 | Athletic Bilbao | Real Sociedad | 4:0 |
| 21-02-22 20:00 | Celta Vigo | UD Levante | 1:1 |