| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 11-02-22 20:00 | FC Sevilla | FC Elche | 2:0 |
| 12-02-22 13:00 | FC Cádiz | Celta Vigo | 0:0 |
| 12-02-22 15:15 | FC Villarreal | Real Madrid | 0:0 |
| 12-02-22 17:30 | Rayo Vallecano | CA Osasuna | 0:3 |
| 12-02-22 20:00 | Atlético Madrid | FC Getafe | 4:3 |
| 13-02-22 13:00 | Deportivo Alavés | FC Valencia | 2:1 |
| 13-02-22 15:15 | UD Levante | Real Betis Sevilla | 2:4 |
| 13-02-22 17:30 | Real Sociedad | FC Granada | 2:0 |
| 13-02-22 20:00 | Espanyol Barcelona | FC Barcelona | 2:2 |
| 14-02-22 20:00 | RCD Mallorca | Athletic Bilbao | 3:2 |