| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 04-02-22 20:00 | FC Getafe | UD Levante | 3:0 |
| 05-02-22 13:00 | FC Elche | Deportivo Alavés | 3:1 |
| 05-02-22 15:15 | RCD Mallorca | FC Cádiz | 2:1 |
| 05-02-22 17:30 | Celta Vigo | Rayo Vallecano | 2:0 |
| 05-02-22 20:00 | CA Osasuna | FC Sevilla | 0:0 |
| 06-02-22 13:00 | FC Valencia | Real Sociedad | 0:0 |
| 06-02-22 15:15 | FC Barcelona | Atlético Madrid | 4:2 |
| 06-02-22 17:30 | Real Betis Sevilla | FC Villarreal | 0:2 |
| 06-02-22 20:00 | Real Madrid | FC Granada | 1:0 |
| 07-02-22 20:00 | Athletic Bilbao | Espanyol Barcelona | 2:1 |