| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-01-22 20:00 | Espanyol Barcelona | Real Betis Sevilla | 1:4 |
| 22-01-22 13:00 | UD Levante | FC Cádiz | 0:2 |
| 22-01-22 15:15 | FC Villarreal | RCD Mallorca | 3:0 |
| 22-01-22 17:30 | FC Sevilla | Celta Vigo | 2:2 |
| 22-01-22 20:00 | Atlético Madrid | FC Valencia | 3:2 |
| 23-01-22 13:00 | FC Granada | CA Osasuna | 0:2 |
| 23-01-22 15:15 | Real Madrid | FC Elche | 2:2 |
| 23-01-22 17:30 | Rayo Vallecano | Athletic Bilbao | 0:1 |
| 23-01-22 17:30 | Real Sociedad | FC Getafe | 0:0 |
| 23-01-22 20:00 | Deportivo Alavés | FC Barcelona | 0:1 |