| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 22-12-21 20:30 | Athletic Bilbao | Real Madrid | 1:2 |
| 16-01-22 13:00 | FC Elche | FC Villarreal | 1:0 |
| 18-01-22 19:00 | Real Betis Sevilla | Deportivo Alavés | 4:0 |
| 18-01-22 20:30 | FC Cádiz | Espanyol Barcelona | 2:2 |
| 19-01-22 18:00 | Celta Vigo | CA Osasuna | 2:0 |
| 19-01-22 20:30 | FC Valencia | FC Sevilla | 1:1 |
| 20-01-22 18:00 | FC Getafe | FC Granada | 4:2 |
| 16-02-22 18:00 | Atlético Madrid | UD Levante | 0:1 |
| 02-03-22 20:00 | RCD Mallorca | Real Sociedad | 0:2 |
| 24-04-22 20:00 | FC Barcelona | Rayo Vallecano | 0:1 |