| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 08-01-22 13:00 | UD Levante | RCD Mallorca | 2:0 |
| 08-01-22 15:15 | Real Sociedad | Celta Vigo | 1:0 |
| 08-01-22 17:30 | FC Granada | FC Barcelona | 1:1 |
| 08-01-22 20:00 | Real Madrid | FC Valencia | 4:1 |
| 09-01-22 13:00 | Rayo Vallecano | Real Betis Sevilla | 1:1 |
| 09-01-22 15:15 | FC Sevilla | FC Getafe | 1:0 |
| 09-01-22 17:30 | CA Osasuna | FC Cádiz | 2:0 |
| 09-01-22 17:30 | Deportivo Alavés | Athletic Bilbao | 0:0 |
| 09-01-22 20:00 | FC Villarreal | Atlético Madrid | 2:2 |
| 10-01-22 20:00 | Espanyol Barcelona | FC Elche | 1:2 |