| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 20-08-21 20:00 | Real Betis Sevilla | FC Cádiz | 1:1 |
| 21-08-21 16:00 | Deportivo Alavés | RCD Mallorca | 0:1 |
| 21-08-21 18:30 | FC Granada | FC Valencia | 1:1 |
| 21-08-21 18:30 | Espanyol Barcelona | FC Villarreal | 0:0 |
| 21-08-21 21:00 | Athletic Bilbao | FC Barcelona | 1:1 |
| 22-08-21 16:00 | Real Sociedad | Rayo Vallecano | 1:0 |
| 22-08-21 18:30 | Atlético Madrid | FC Elche | 1:0 |
| 22-08-21 21:00 | UD Levante | Real Madrid | 3:3 |
| 23-08-21 19:00 | FC Getafe | FC Sevilla | 0:1 |
| 23-08-21 21:00 | CA Osasuna | Celta Vigo | 0:0 |