| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 31-12-21 15:15 | FC Valencia | Espanyol Barcelona | 1:2 |
| 02-01-22 13:00 | FC Getafe | Real Madrid | 1:0 |
| 02-01-22 15:15 | Atlético Madrid | Rayo Vallecano | 2:0 |
| 02-01-22 15:15 | FC Elche | FC Granada | 0:0 |
| 02-01-22 17:30 | Deportivo Alavés | Real Sociedad | 1:1 |
| 02-01-22 17:30 | Real Betis Sevilla | Celta Vigo | 0:2 |
| 02-01-22 20:00 | RCD Mallorca | FC Barcelona | 0:1 |
| 03-01-22 18:00 | FC Villarreal | UD Levante | 5:0 |
| 03-01-22 20:05 | CA Osasuna | Athletic Bilbao | 1:3 |
| 03-01-22 20:15 | FC Cádiz | FC Sevilla | 0:1 |