| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 17-12-21 20:00 | Celta Vigo | Espanyol Barcelona | 3:1 |
| 18-12-21 13:00 | Rayo Vallecano | Deportivo Alavés | 2:0 |
| 18-12-21 15:15 | Real Sociedad | FC Villarreal | 1:3 |
| 18-12-21 17:30 | FC Barcelona | FC Elche | 3:2 |
| 18-12-21 20:00 | FC Sevilla | Atlético Madrid | 2:1 |
| 19-12-21 13:00 | FC Granada | RCD Mallorca | 4:1 |
| 19-12-21 15:15 | Athletic Bilbao | Real Betis Sevilla | 3:2 |
| 19-12-21 17:30 | FC Getafe | CA Osasuna | 1:0 |
| 19-12-21 20:00 | Real Madrid | FC Cádiz | 0:0 |
| 20-12-21 20:00 | UD Levante | FC Valencia | 3:4 |