| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 10-12-21 20:00 | RCD Mallorca | Celta Vigo | 0:0 |
| 11-12-21 13:00 | Espanyol Barcelona | UD Levante | 4:3 |
| 11-12-21 15:15 | Deportivo Alavés | FC Getafe | 1:1 |
| 11-12-21 17:30 | FC Valencia | FC Elche | 2:1 |
| 11-12-21 20:00 | Athletic Bilbao | FC Sevilla | 0:1 |
| 12-12-21 13:00 | FC Villarreal | Rayo Vallecano | 2:0 |
| 12-12-21 15:15 | CA Osasuna | FC Barcelona | 2:2 |
| 12-12-21 17:30 | Real Betis Sevilla | Real Sociedad | 4:0 |
| 12-12-21 20:00 | Real Madrid | Atlético Madrid | 2:0 |
| 13-12-21 20:00 | FC Cádiz | FC Granada | 1:1 |