| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 03-12-21 20:00 | FC Granada | Deportivo Alavés | 2:1 |
| 04-12-21 13:00 | FC Sevilla | FC Villarreal | 1:0 |
| 04-12-21 15:15 | FC Barcelona | Real Betis Sevilla | 0:1 |
| 04-12-21 17:30 | Atlético Madrid | RCD Mallorca | 1:2 |
| 04-12-21 20:00 | Real Sociedad | Real Madrid | 0:2 |
| 05-12-21 13:00 | Rayo Vallecano | Espanyol Barcelona | 1:0 |
| 05-12-21 15:15 | FC Elche | FC Cádiz | 3:1 |
| 05-12-21 17:30 | UD Levante | CA Osasuna | 0:0 |
| 05-12-21 20:00 | Celta Vigo | FC Valencia | 1:2 |
| 06-12-21 20:00 | FC Getafe | Athletic Bilbao | 0:0 |