| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 26-11-21 20:00 | Athletic Bilbao | FC Granada | 2:2 |
| 27-11-21 13:00 | Deportivo Alavés | Celta Vigo | 1:2 |
| 27-11-21 15:15 | FC Valencia | Rayo Vallecano | 1:1 |
| 27-11-21 17:30 | RCD Mallorca | FC Getafe | 0:0 |
| 27-11-21 20:00 | FC Villarreal | FC Barcelona | 1:3 |
| 28-11-21 13:00 | Real Betis Sevilla | UD Levante | 3:1 |
| 28-11-21 15:15 | Espanyol Barcelona | Real Sociedad | 1:0 |
| 28-11-21 17:30 | FC Cádiz | Atlético Madrid | 1:4 |
| 28-11-21 20:00 | Real Madrid | FC Sevilla | 2:1 |
| 29-11-21 20:00 | CA Osasuna | FC Elche | 1:1 |