| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 19-11-21 20:00 | UD Levante | Athletic Bilbao | 0:0 |
| 20-11-21 13:00 | Celta Vigo | FC Villarreal | 1:1 |
| 20-11-21 15:15 | FC Sevilla | Deportivo Alavés | 2:2 |
| 20-11-21 17:30 | Atlético Madrid | CA Osasuna | 1:0 |
| 20-11-21 20:00 | FC Barcelona | Espanyol Barcelona | 1:0 |
| 21-11-21 13:00 | FC Getafe | FC Cádiz | 4:0 |
| 21-11-21 15:15 | FC Granada | Real Madrid | 1:4 |
| 21-11-21 17:30 | FC Elche | Real Betis Sevilla | 0:3 |
| 21-11-21 20:00 | Real Sociedad | FC Valencia | 0:0 |
| 22-11-21 20:00 | Rayo Vallecano | RCD Mallorca | 3:1 |