| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 05-11-21 20:00 | Athletic Bilbao | FC Cádiz | 0:1 |
| 06-11-21 13:00 | Espanyol Barcelona | FC Granada | 2:0 |
| 06-11-21 15:15 | Celta Vigo | FC Barcelona | 3:3 |
| 06-11-21 17:30 | Deportivo Alavés | UD Levante | 2:1 |
| 06-11-21 20:00 | Real Madrid | Rayo Vallecano | 2:1 |
| 07-11-21 13:00 | FC Villarreal | FC Getafe | 1:0 |
| 07-11-21 15:15 | FC Valencia | Atlético Madrid | 3:3 |
| 07-11-21 17:30 | CA Osasuna | Real Sociedad | 0:2 |
| 07-11-21 17:30 | RCD Mallorca | FC Elche | 2:2 |
| 07-11-21 20:00 | Real Betis Sevilla | FC Sevilla | 0:2 |