| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 26-10-21 18:00 | Deportivo Alavés | FC Elche | 1:0 |
| 26-10-21 20:00 | Espanyol Barcelona | Athletic Bilbao | 1:1 |
| 26-10-21 20:30 | FC Villarreal | FC Cádiz | 3:3 |
| 27-10-21 18:00 | Rayo Vallecano | FC Barcelona | 1:0 |
| 27-10-21 18:00 | RCD Mallorca | FC Sevilla | 1:1 |
| 27-10-21 19:00 | Real Betis Sevilla | FC Valencia | 4:1 |
| 27-10-21 20:30 | Real Madrid | CA Osasuna | 0:0 |
| 28-10-21 18:00 | Celta Vigo | Real Sociedad | 0:2 |
| 28-10-21 19:00 | FC Granada | FC Getafe | 1:1 |
| 28-10-21 20:30 | UD Levante | Atlético Madrid | 2:2 |