| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 22-10-21 20:00 | CA Osasuna | FC Granada | 1:1 |
| 23-10-21 13:00 | FC Valencia | RCD Mallorca | 2:2 |
| 23-10-21 15:15 | FC Cádiz | Deportivo Alavés | 0:2 |
| 23-10-21 17:30 | FC Elche | Espanyol Barcelona | 2:2 |
| 23-10-21 20:00 | Athletic Bilbao | FC Villarreal | 2:1 |
| 24-10-21 13:00 | FC Sevilla | UD Levante | 5:3 |
| 24-10-21 15:15 | FC Barcelona | Real Madrid | 1:2 |
| 24-10-21 17:30 | Real Betis Sevilla | Rayo Vallecano | 3:2 |
| 24-10-21 20:00 | Atlético Madrid | Real Sociedad | 2:2 |
| 25-10-21 20:00 | FC Getafe | Celta Vigo | 0:3 |