| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 13-08-21 20:00 | FC Valencia | FC Getafe | 1:0 |
| 14-08-21 18:30 | FC Cádiz | UD Levante | 1:1 |
| 14-08-21 18:30 | RCD Mallorca | Real Betis Sevilla | 1:1 |
| 14-08-21 21:00 | CA Osasuna | Espanyol Barcelona | 0:0 |
| 14-08-21 21:00 | Deportivo Alavés | Real Madrid | 1:4 |
| 15-08-21 16:30 | Celta Vigo | Atlético Madrid | 1:2 |
| 15-08-21 19:00 | FC Barcelona | Real Sociedad | 4:2 |
| 15-08-21 21:15 | FC Sevilla | Rayo Vallecano | 3:0 |
| 16-08-21 19:00 | FC Villarreal | FC Granada | 0:0 |
| 16-08-21 21:00 | FC Elche | Athletic Bilbao | 0:0 |