| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 15-05-22 14:30 | Werder Bremen | Jahn Regensburg | 2:0 |
| 15-05-22 14:30 | SV Darmstadt 98 | SC Paderborn 07 | 3:0 |
| 15-05-22 14:30 | 1. FC Heidenheim 1846 | Karlsruher SC | 2:0 |
| 15-05-22 14:30 | FC St. Pauli | Fortuna Düsseldorf | 2:0 |
| 15-05-22 14:30 | 1. FC Nuremberga | FC Schalke 04 | 1:2 |
| 15-05-22 14:30 | Hannover 96 | FC Ingolstadt | 3:2 |
| 15-05-22 14:30 | SV Sandhausen | Holstein Kiel | 3:1 |
| 15-05-22 14:30 | Dynamo Dresden | Erzgebirge Aue | 0:1 |
| 15-05-22 14:30 | FC Hansa Rostock | Hamburgo SV | 2:3 |