| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 27-10-20 18:00 | FC Girona | FC Cartagena | 2:1 |
| 28-10-20 18:00 | Albacete Balompie | UD Las Palmas | 1:1 |
| 28-10-20 18:00 | Espanyol Barcelona | SD Ponferradina | 2:0 |
| 28-10-20 18:00 | CD Castellón | UD Almeria | 1:2 |
| 28-10-20 20:30 | Real Oviedo | UD Logroñés | 2:3 |
| 29-10-20 15:30 | AD Alcorcón | Sporting Gijón | 1:2 |
| 29-10-20 18:00 | CD Teneriffa | CD Lugo | 1:1 |
| 29-10-20 18:00 | CD Mirandés | Real Zaragoza | 1:0 |
| 29-10-20 18:00 | RCD Mallorca | FC Málaga | 3:1 |
| 29-10-20 20:30 | CD Sabadell | CD Leganés | 1:0 |
| 29-10-20 20:30 | Rayo Vallecano | CF Fuenlabrada | 2:0 |