| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 18-05-21 18:00 | FC Cartagena | UD Almeria | 3:2 |
| 18-05-21 20:30 | Albacete Balompie | CD Lugo | 1:1 |
| 18-05-21 20:30 | SD Ponferradina | Espanyol Barcelona | 1:4 |
| 19-05-21 18:00 | UD Logroñés | CF Fuenlabrada | 1:0 |
| 19-05-21 18:00 | AD Alcorcón | CD Sabadell | 2:0 |
| 19-05-21 20:30 | CD Mirandés | CD Leganés | 0:0 |
| 19-05-21 20:30 | CD Teneriffa | RCD Mallorca | 0:1 |
| 20-05-21 18:00 | FC Málaga | FC Girona | 0:1 |
| 20-05-21 18:00 | Sporting Gijón | UD Las Palmas | 1:0 |
| 20-05-21 20:30 | Rayo Vallecano | Real Oviedo | 4:1 |
| 20-05-21 20:30 | Real Zaragoza | CD Castellón | 3:0 |