| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 14-05-21 20:00 | Espanyol Barcelona | FC Cartagena | 0:2 |
| 15-05-21 15:00 | CD Castellón | SD Ponferradina | 0:2 |
| 15-05-21 17:30 | CD Lugo | CD Mirandés | 2:1 |
| 15-05-21 20:00 | UD Las Palmas | Real Zaragoza | 0:2 |
| 15-05-21 20:00 | UD Almeria | Albacete Balompie | 1:1 |
| 16-05-21 13:00 | CD Sabadell | CD Teneriffa | 0:2 |
| 16-05-21 15:00 | CF Fuenlabrada | Rayo Vallecano | 1:2 |
| 16-05-21 19:45 | RCD Mallorca | AD Alcorcón | 2:0 |
| 16-05-21 20:30 | CD Leganés | UD Logroñés | 3:0 |
| 17-05-21 18:00 | Real Oviedo | FC Málaga | 1:0 |
| 17-05-21 20:00 | FC Girona | Sporting Gijón | 1:0 |