| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 07-05-21 20:00 | CD Teneriffa | UD Almeria | 0:1 |
| 08-05-21 17:15 | SD Ponferradina | Albacete Balompie | 0:1 |
| 08-05-21 17:15 | Real Zaragoza | Espanyol Barcelona | 0:0 |
| 08-05-21 19:30 | AD Alcorcón | UD Las Palmas | 0:0 |
| 08-05-21 20:00 | FC Málaga | RCD Mallorca | 1:1 |
| 09-05-21 13:00 | CD Mirandés | CF Fuenlabrada | 2:1 |
| 09-05-21 15:00 | Real Oviedo | CD Sabadell | 2:1 |
| 09-05-21 17:15 | UD Logroñés | FC Girona | 1:4 |
| 09-05-21 17:15 | FC Cartagena | CD Castellón | 1:0 |
| 10-05-21 18:00 | Rayo Vallecano | CD Leganés | 1:1 |
| 10-05-21 20:00 | Sporting Gijón | CD Lugo | 1:0 |