| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 23-04-21 20:00 | Real Zaragoza | Sporting Gijón | 0:0 |
| 24-04-21 15:00 | UD Logroñés | FC Cartagena | 0:1 |
| 24-04-21 15:00 | FC Málaga | CF Fuenlabrada | 0:1 |
| 24-04-21 17:15 | Espanyol Barcelona | UD Las Palmas | 4:0 |
| 24-04-21 19:30 | SD Ponferradina | CD Lugo | 2:0 |
| 25-04-21 13:00 | Real Oviedo | FC Girona | 0:1 |
| 25-04-21 15:00 | CD Mirandés | UD Almeria | 1:1 |
| 25-04-21 17:15 | AD Alcorcón | CD Leganés | 1:2 |
| 25-04-21 19:30 | CD Teneriffa | CD Castellón | 1:1 |
| 26-04-21 18:00 | Rayo Vallecano | Albacete Balompie | 2:2 |
| 26-04-21 20:00 | CD Sabadell | RCD Mallorca | 1:0 |