| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 16-04-21 18:00 | CF Fuenlabrada | CD Sabadell | 2:2 |
| 16-04-21 20:00 | FC Girona | Real Zaragoza | 3:0 |
| 17-04-21 13:00 | CD Lugo | AD Alcorcón | 1:3 |
| 17-04-21 15:00 | CD Castellón | RCD Mallorca | 1:0 |
| 17-04-21 17:15 | Sporting Gijón | Real Oviedo | 0:1 |
| 17-04-21 17:15 | UD Las Palmas | FC Málaga | 1:1 |
| 18-04-21 13:00 | UD Logroñés | Rayo Vallecano | 0:0 |
| 18-04-21 13:00 | Albacete Balompie | CD Mirandés | 1:0 |
| 18-04-21 17:15 | FC Cartagena | CD Teneriffa | 0:0 |
| 19-04-21 18:00 | CD Leganés | SD Ponferradina | 1:1 |
| 19-04-21 20:00 | UD Almeria | Espanyol Barcelona | 1:1 |