| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 09-04-21 20:00 | CD Teneriffa | Sporting Gijón | 1:0 |
| 10-04-21 13:00 | SD Ponferradina | CF Fuenlabrada | 0:0 |
| 10-04-21 15:00 | Real Oviedo | UD Las Palmas | 0:0 |
| 10-04-21 17:15 | Rayo Vallecano | FC Girona | 2:1 |
| 11-04-21 13:00 | FC Málaga | Albacete Balompie | 2:0 |
| 11-04-21 15:00 | Real Zaragoza | UD Almeria | 2:1 |
| 11-04-21 17:15 | RCD Mallorca | CD Lugo | 2:0 |
| 11-04-21 17:15 | CD Mirandés | UD Logroñés | 0:1 |
| 11-04-21 17:15 | CD Sabadell | FC Cartagena | 1:1 |
| 11-04-21 20:00 | Espanyol Barcelona | CD Leganés | 2:1 |
| 12-04-21 20:00 | AD Alcorcón | CD Castellón | 2:1 |