| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 02-04-21 20:00 | UD Almeria | Rayo Vallecano | 0:1 |
| 03-04-21 13:00 | UD Logroñés | CD Teneriffa | 1:0 |
| 03-04-21 15:00 | FC Girona | SD Ponferradina | 3:1 |
| 03-04-21 17:15 | CD Castellón | Real Oviedo | 1:0 |
| 04-04-21 13:00 | Sporting Gijón | CD Mirandés | 1:2 |
| 04-04-21 15:00 | Albacete Balompie | Espanyol Barcelona | 0:3 |
| 04-04-21 17:15 | CD Leganés | CD Sabadell | 2:1 |
| 04-04-21 17:15 | CD Lugo | FC Málaga | 0:1 |
| 04-04-21 19:30 | UD Las Palmas | RCD Mallorca | 1:1 |
| 05-04-21 18:00 | FC Cartagena | AD Alcorcón | 2:1 |
| 05-04-21 20:00 | CF Fuenlabrada | Real Zaragoza | 0:1 |