| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 19-03-21 20:00 | UD Las Palmas | FC Girona | 1:2 |
| 20-03-21 15:00 | CD Sabadell | Sporting Gijón | 1:1 |
| 20-03-21 17:15 | RCD Mallorca | Real Oviedo | 0:0 |
| 20-03-21 19:30 | CD Leganés | CF Fuenlabrada | 0:2 |
| 20-03-21 20:00 | Espanyol Barcelona | UD Logroñés | 4:0 |
| 21-03-21 13:00 | SD Ponferradina | UD Almeria | 2:1 |
| 21-03-21 15:00 | FC Málaga | CD Teneriffa | 1:1 |
| 21-03-21 17:15 | CD Lugo | CD Castellón | 0:0 |
| 21-03-21 19:30 | AD Alcorcón | Rayo Vallecano | 0:3 |
| 22-03-21 18:00 | Albacete Balompie | FC Cartagena | 2:0 |
| 22-03-21 20:00 | Real Zaragoza | CD Mirandés | 1:0 |