| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 12-03-21 18:00 | FC Cartagena | SD Ponferradina | 1:1 |
| 12-03-21 20:00 | Rayo Vallecano | Real Zaragoza | 3:2 |
| 13-03-21 15:00 | CF Fuenlabrada | UD Las Palmas | 1:2 |
| 13-03-21 17:15 | FC Girona | CD Lugo | 1:1 |
| 13-03-21 19:30 | CD Castellón | CD Sabadell | 2:1 |
| 13-03-21 20:00 | CD Mirandés | Espanyol Barcelona | 2:2 |
| 14-03-21 13:00 | UD Logroñés | FC Málaga | 0:1 |
| 14-03-21 15:00 | Sporting Gijón | RCD Mallorca | 2:0 |
| 14-03-21 17:15 | CD Teneriffa | Albacete Balompie | 2:0 |
| 14-03-21 19:30 | Real Oviedo | CD Leganés | 1:3 |
| 15-03-21 18:00 | UD Almeria | AD Alcorcón | 0:0 |