| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 05-03-21 20:00 | Espanyol Barcelona | Real Oviedo | 1:1 |
| 06-03-21 15:00 | Real Zaragoza | CD Teneriffa | 1:0 |
| 06-03-21 17:15 | UD Las Palmas | Rayo Vallecano | 1:1 |
| 06-03-21 17:15 | CD Leganés | CD Castellón | 0:0 |
| 06-03-21 19:30 | Albacete Balompie | UD Logroñés | 1:1 |
| 07-03-21 13:00 | FC Málaga | CD Sabadell | 2:0 |
| 07-03-21 15:00 | SD Ponferradina | Sporting Gijón | 2:2 |
| 07-03-21 17:15 | RCD Mallorca | FC Cartagena | 2:1 |
| 07-03-21 20:00 | FC Girona | UD Almeria | 0:1 |
| 08-03-21 18:00 | AD Alcorcón | CD Mirandés | 4:0 |
| 08-03-21 20:00 | CD Lugo | CF Fuenlabrada | 0:0 |