| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 19-02-21 20:00 | SD Ponferradina | CD Mirandés | 1:0 |
| 20-02-21 15:00 | Espanyol Barcelona | CD Sabadell | 1:0 |
| 20-02-21 17:15 | Albacete Balompie | Sporting Gijón | 0:1 |
| 20-02-21 19:30 | UD Las Palmas | FC Cartagena | 2:0 |
| 21-02-21 13:00 | CD Leganés | CD Teneriffa | 1:0 |
| 21-02-21 15:00 | RCD Mallorca | UD Almeria | 2:0 |
| 21-02-21 17:15 | FC Girona | CD Castellón | 2:1 |
| 21-02-21 19:30 | CD Lugo | UD Logroñés | 1:1 |
| 21-02-21 20:00 | FC Málaga | Rayo Vallecano | 2:0 |
| 22-02-21 18:00 | CF Fuenlabrada | Real Oviedo | 2:2 |
| 22-02-21 20:00 | Real Zaragoza | AD Alcorcón | 0:1 |