| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 12-02-21 20:00 | CD Sabadell | Real Zaragoza | 1:1 |
| 13-02-21 15:00 | FC Cartagena | Rayo Vallecano | 2:2 |
| 13-02-21 17:15 | CD Mirandés | FC Girona | 3:3 |
| 13-02-21 19:30 | CD Teneriffa | SD Ponferradina | 1:0 |
| 14-02-21 13:00 | RCD Mallorca | Espanyol Barcelona | 1:2 |
| 14-02-21 15:00 | UD Almeria | UD Las Palmas | 3:1 |
| 14-02-21 17:15 | CD Leganés | Albacete Balompie | 3:1 |
| 14-02-21 17:15 | AD Alcorcón | UD Logroñés | 1:0 |
| 14-02-21 20:00 | Sporting Gijón | FC Málaga | 1:0 |
| 15-02-21 18:00 | CD Castellón | CF Fuenlabrada | 1:2 |
| 15-02-21 20:00 | Real Oviedo | CD Lugo | 3:1 |